Macrophage migration inhibitory factor (MIF)
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine encoded within a functionally polymorphic genetic locus. MIF is a highly conserved 12.5 kDa secretory protein that is involved in numerous biological processes. The expression and secretion profile of MIF suggests that MIF to be ubiquitously and constitutively expressed in almost all mammalian cells and is vital for numerous physiological processes. MIF is a pleiotropic inflammatory cytokine important in the upstream regulation of both innate and adaptive immunological responses and has been implicated in the pathogenesis of autoimmune diseases including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
All Product Categories
-
Macrophage migration inhibitory factor (MIF) Related Products (28)
Related Products (28)
- 1
- 2
-
ISO-1
0 ImagesSynonyms: MIF AntagonistISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.
-
4-IPP
0 ImagesSynonyms: 4-Iodo-6-phenylpyrimidine4-IPP (4-Iodo-6-phenylpyrimidine) is a specific suicide substrate and irreversible inhibitor of macrophage migration inhibitory factor (MIF).
-
Iguratimod
0 ImagesSynonyms: T614Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC50 of 6.81 μM.
-
MIF098
0 ImagesMIF098 is a macrophage migration inhibitory factor (MIF) antagonist. MIF098 inhibits proliferation, migration and fibrosis of pulmonary smooth muscle cells. MIF098 can be used for immunoinflammation-related disease research.
-
D-DT/MIF-1-IN-1
0 ImagesCat. No.: HY-181912CAS No.: 1461756-61-5D-DT/MIF-1-IN-1 (Compound 4h) is a non-competitive, non-covalent inhibitor of MIF-1 and D-DT, with IC50 values of 2.4 μM and 4.0 μM against D-DT, and an IC50 value of 9.8 μM against MIF-1. D-DT/MIF-1-IN-1 inhibits D-DT-induced phosphorylation of ERK and exerts antiproliferative activity in non-small cell lung cancer cells.
-
PAANIB-1
0 ImagesCat. No.: HY-182935CAS No.: 2634726-71-7PAANIB-1 is a parthanatos associated apoptosis-inducing factor nuclease (PAAN)/macrophage migration inhibitor factor (MIF) inhibitor. PAANIB-1 exhibits neuroprotective activity. PAANIB-1 can be used for the research of Parkinson's disease.
-
(±)-CPSI-1306
0 Images(±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF).
-
Mitomycin A
0 ImagesMitomycin A is an antitumor agent. Mitomycin A inhibits the spontaneous migration of mouse monocytes. Mitomycin A inhibits the production of MIF (Migration Inhibition Factor) by human lymphocytes. Mitomycin A can be used in the research of tumor diseases.
-
MD13
0 ImagesMD13 is a MIF PROTAC degrader with a DC50 of approximately 100 nM. MD13 induces ubiquitination and degradation of MIF by recruiting the Cereblon Cullin RING E3 ubiquitin ligase complex. MD13 inactivates the MAPK pathway and induces G2/M phase cell cycle arrest. MD13 exhibits antiproliferative effects in 3D tumor spheroid models. MD13 can be used in lung cancer-related research.
-
BTZO-1
0 ImagesBTZO-1, a chemical probe, binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro.
-
4-CPPC
0 Images4-CPPC is a potent, reversible and selective MIF-2 inhibitor with Ki values of 431, 33 µM for MIF-1, MIF-2, respectively.
-
RDR 03785
0 ImagesCat. No.: HY-W164560CAS No.: 289657-30-3RDR 03785 is a covalent MIF inhibitor with an IC50 of 0.36 μM.
-
MKA031
0 ImagesMKA031 (compound 6y) is a non-competitive MIF inhibitor with an IC50 value of 1.7 μM. MKA031 (compound 6y) interferes with MIF/AIF interaction, MIF nuclear translocation, and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced dependent cell death. MKA031 can be used in the study of chronic hepatitis C virus infection.
-
R110
0 ImagesR110 is a potent, competitive inhibitor of macrophage migration inhibitory factor 2 (MIF2) tautomerase with an IC50 of 15 μM. R110 has the potential for the research of cancer diseases.
-
TE-11
0 ImagesCat. No.: HY-173624CAS No.: 160488-11-9TE-11 is a MIF tautomerase inhibitor with an IC50 of 5.63 μM. TE-11 ameliorates CD-like colitis, reduces MIF-induced eosinophil and neutrophil migration, and prevents M1 polarization and associated metabolic reprogramming.
-
MIF2-IN-1
0 ImagesCat. No.: HY-115888CAS No.: 2917525-79-0MIF2-IN-1 (compound 5d) is a potent inhibitor of MIF2 tautomerase with an IC50 of 1.0 μM. MIF2-IN-1 suppresses the proliferation of non-small cell lung cancer cells by the induction of cell cycle arrest via deactivation of the MAPK pathway. MIF2-IN-1 has the potential for the research of cancer diseases.
-
MIF-IN-4 hydrochloride
0 ImagesCat. No.: HY-144196CAS No.: 2489514-05-6MIF-IN-4 hydrochloride is potent macrophage migration inhibitory factor (MIF) inhibitor (pIC50=5.01-6). MIF is a cytokine originally found to play a role in inhibiting macrophage migration.
-
MIF-IN-6
0 ImagesCat. No.: HY-146319CAS No.: 2582758-61-8MIF-IN-6 (compound 2d) is a potent macrophage migration inhibitory factor (MIF) inhibitor with an IC50 of 1.4 μM and a Ki value of 0.96 μM, respectively. MIF-IN-6 attenuates MIF-induced ERK phosphorylation and inhibits proliferation of A549 cells.
- 1
- 2
